The activity of dispiro peroxides against Fasciola hepatica.
Bioorg Med Chem Lett
; 21(18): 5320-3, 2011 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-21802291
ABSTRACT
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Tetraoxanos
/
Fasciola hepatica
/
Compostos Heterocíclicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article