All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27.
Cancer Lett
; 310(2): 232-9, 2011 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-21803488
ABSTRACT
We here present a new anti-tumor mechanism of all-trans retinoic acid (ATRA). ATRA induced several biomarkers of cellular senescence including irreversible G1 arrest, morphological changes, senescence-associated ß-galactosidase, and heterochromatin foci in HepG2 cells. ATRA also upregulated levels of p16, p21, and p27 which lead to activation of Rb and subsequent inactivation of E2F1. These effects were abolished by the RNA interference-mediated silencing of p16, p21, and p27. Moreover, ATRA failed to induce cellular senescence in Huh7 and HCT116, in which p16, p21, and p27 were not upregulated by ATRA, confirming that ATRA induces cellular senescence via upregulation of p16, p21, and p27.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
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Senescência Celular
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Inibidor de Quinase Dependente de Ciclina p21
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Inibidor de Quinase Dependente de Ciclina p27
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Proteínas de Neoplasias
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article