Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion.
Colloids Surf B Biointerfaces
; 88(1): 505-11, 2011 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-21821399
ABSTRACT
Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH(4)) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH(4). PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polietilenoimina
/
Prata
/
Coloides
/
Nanopartículas Metálicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article