Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.
Antimicrob Agents Chemother
; 55(11): 5362-6, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21825300
ABSTRACT
Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and in vitro phenotype analyses of samples with increased scores showed no reduced tipranavir susceptibility. Current algorithms appear suboptimal for interpretation of resistance to tipranavir in non-B subtypes; increased scores might reflect algorithm bias rather than "natural resistance."
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Pironas
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Infecções por HIV
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Inibidores da Protease de HIV
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Fármacos Anti-HIV
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Farmacorresistência Viral
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article