Antagonists of luteinizing hormone releasing hormone with novel unnatural amino acids at position six.
Int J Pept Protein Res
; 35(2): 157-60, 1990 Feb.
Article
em En
| MEDLINE
| ID: mdl-2182559
ABSTRACT
Five new antagonists of luteinizing hormone releasing hormone (LHRH) containing novel unnatural amino acids at position six are reported. They are very effective in the rat antiovulatory assay. Using saline as vehicle, antagonist-[N-Ac-D-2-Nal1, D-4-Cl-Phe2, D-3-Pal3, Arg5, D-A26, D-Ala10]-LHRH inhibited ovulation completely at 1 micrograms/rat and three of the other antagonists showed some antiovulatory activity at 0.5 micrograms/rat.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Hormônio Liberador de Gonadotropina
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article