[Chemical constituents of aerial parts of Gelsemium elegans].
Zhongguo Zhong Yao Za Zhi
; 36(10): 1305-10, 2011 May.
Article
em Zh
| MEDLINE
| ID: mdl-21837971
ABSTRACT
OBJECTIVE:
To study the chemical constituents from the aerial parts of Gelsemium elegans.METHOD:
Compounds were isolated and purified by repeated column chromatography, as well as semiprep arative HPLC, and their structures were identified by physicochemical properties and spectroscopic methods, such as NMR and MS.RESULT:
Sixteen compounds were obtained and identified from G. elegans, including nine alkaloids koumine (1), gelsenicine (2), 19-(Z)-akuammidine (3), gelsemoxonine(4), gelsemin (5), gelsevirine (6), humantenine (7), 11-methoxygelsemamide (8) and gelegamine D (9). Three megastigmane glycosides (3R, 5S, 6S, 7E, 9R)-megastigman-7-ene-3, 5, 6, 9-tetrol-9-O-beta-D-glucopyranoside (10), (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside] (11) and (6S, 7E, 9R) -6, 9-dihydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6) -beta-D-glucopyranoside] (12). Two flavone C-glycosides orientin (13) and isorientin (14); one iridoid glycoside, sweroside (15) and one fructoside, n-butyl-alpha-D-fructofuranoside (16).CONCLUSION:
Compounds 10-16 were isolated from the genus Gelsemium for the first time.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Gelsemium
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article