Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine.
Org Lett
; 13(18): 4786-9, 2011 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-21842835
ABSTRACT
Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic structure are reported.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Veratrum
/
Transdução de Sinais
/
Estrona
/
Proteínas Hedgehog
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article