Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.
Blood
; 118(15): 4174-8, 2011 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-21856866
ABSTRACT
Initial cell surface expression of the pre-B cell receptor induces proliferation. After 2 to 5 divisions, however, large pre-BII (Fraction C') cells exit cell cycle to become resting, small pre-BII cells (Fraction D). The mechanism by which pre-BII cells exit cell cycle, however, is currently unclear. The checkpoint at the Fraction C'-D transition is critical for immunoglobulin light chain gene recombination and to prevent malignant transformation into acute lymphoblastic leukemia. Here we demonstrate that inducible activation of pre-B cell receptor signaling induces cell-cycle exit through up-regulation of the transcriptional repressor BCL6. Inducible activation of BCL6 downstream of the pre-B cell receptor results in transcriptional repression of MYC and CCND2. Hence, pre-B cell receptor-mediated activation of BCL6 limits pre-B cell proliferation and induces cellular quiescence at the small pre-BII (Fraction D) stage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Divisão Celular
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Proteínas Proto-Oncogênicas c-myc
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Proteínas de Ligação a DNA
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Células Precursoras de Linfócitos B
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Receptores de Células Precursoras de Linfócitos B
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Pontos de Checagem do Ciclo Celular
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article