Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells.
Anticancer Res
; 31(9): 2699-704, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21868510
ABSTRACT
BACKGROUND:
Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties. MATERIALS ANDMETHODS:
PANC-1 and AsPC-1 human pancreatic cancer cells were used as in vitro models to test the effects of PE.RESULTS:
PE treatment induced cell cycle arrest and inhibited cell proliferation in PANC-1 cells. PE treatment increased the proportion of cells lacking CD44 and CD24 expression, which are associated with increased tumor-initiating ability, demonstrating that PE altered cell phenotype. PE was more effective in inhibiting the proliferation of PANC-1 cells than the clinically used dose of paclitaxel. Similar results were obtained in the AsPC-1 cell line. Individual pomegranate phytochemicals were only modestly effective in inhibiting cell proliferation, suggesting that unidentified phytochemicals are responsible for the inhibitory effect of PE.CONCLUSION:
These data suggest that PE is a promising candidate for further preclinical testing for treatment of human pancreatic cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Extratos Vegetais
/
Ciclo Celular
/
Lythraceae
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article