The anti-cancer and anti-inflammatory actions of 1,25(OH)2D3.
Best Pract Res Clin Endocrinol Metab
; 25(4): 593-604, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21872801
ABSTRACT
Various epidemiological studies have shown an aetiological link between vitamin D deficiency and cancer incidence. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], has potent anti-cancer activities both in vitro and in vivo. These anti-cancer effects are attained by regulating the transcription of numerous genes that are involved in different pathways to reduce tumorigenesis and are dependent on the cancer cell type. Besides reducing cell growth and inducing apoptosis, 1,25(OH)2D3 also inhibits angiogenesis and metastasis. Moreover, its potency to inhibit inflammation also contributes to its anti-tumoral activity. Here, we report the different ways in which 1,25(OH)2D3 interferes with the malignant processes that are activated in cancer cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Calcitriol
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Anti-Inflamatórios não Esteroides
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Anticarcinógenos
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Antineoplásicos
Tipo de estudo:
Etiology_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article