Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
Child Dev
; 82(6): 1797-814, 2011.
Article
em En
| MEDLINE
| ID: mdl-21883161
ABSTRACT
The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22 years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n = 378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Grupo Associado
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Facilitação Social
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Predisposição Genética para Doença
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Receptor Muscarínico M2
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Alelos
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Interação Gene-Ambiente
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Controle Interno-Externo
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Transtorno da Personalidade Antissocial
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article