Platelet satellitism and dual surface immunoglobulin light-chain expression in circulating splenic marginal zone lymphoma cells.
Ann Diagn Pathol
; 17(1): 117-22, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-21889383
ABSTRACT
Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid-anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esplênicas
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Plaquetas
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Cadeias kappa de Imunoglobulina
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Cadeias lambda de Imunoglobulina
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Linfoma de Zona Marginal Tipo Células B
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Neutrófilos
Limite:
Aged80
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Female
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article