Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
Int J Parasitol
; 41(12): 1249-52, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21889508
ABSTRACT
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Schistosoma mansoni
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Tetraspaninas
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Antígenos de Helmintos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Humans
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Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article