Acute toxicity in 14 patients with locally advanced head and neck squamous cell carcinoma treated with concurrent cetuximab and radiotherapy.
Radiol Med
; 117(1): 125-32, 2012 Feb.
Article
em En, It
| MEDLINE
| ID: mdl-21892718
ABSTRACT
PURPOSE:
The authors report acute toxicity in 14 patients with locally advanced head and neck squamous cell carcinoma treated with radiotherapy and cetuximab. MATERIALS ANDMETHODS:
Data collection was performed prospectively on patients treated from September 2007 to March 2009. Treatment consisted of 64.8-70 Gy radiotherapy in conventional fractions and cetuximab.RESULTS:
Two out of 14 patients did not complete the planned combined treatment; radiotherapy was temporarily suspended in six other patients. Seven of 12 patients received cetuximab until the end of radiotherapy. Treatment breaks were principally due to severe acute cutaneous or mucous toxicity. Any grade acneiform rash occurred in all patients. In-field G3-4 cutaneous toxicity occurred in five (36%) patients and G3-4 mucous toxicity in seven (50%). One patient died of sepsis.CONCLUSIONS:
In our experience, severe acute toxic reactions are common in patients treated with radiotherapy and concurrent cetuximab, resulting in frequent breaks or incomplete treatment with potential reduction in disease control.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radiodermite
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Carcinoma de Células Escamosas
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Neoplasias de Cabeça e Pescoço
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Anticorpos Monoclonais
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Antineoplásicos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
País como assunto:
Europa
Idioma:
En
/
It
Ano de publicação:
2012
Tipo de documento:
Article