CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.
Neurosci Lett
; 503(3): 224-8, 2011 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-21896317
ABSTRACT
A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB(1) cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB(1) receptor interacting protein, CRIP1a, was identified and found to alter CB(1) activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Fármacos Neuroprotetores
/
Ácido Glutâmico
/
Aminoácidos Excitatórios
/
Agonistas de Receptores de Canabinoides
/
Antagonistas de Receptores de Canabinoides
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article