Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays.
Am J Obstet Gynecol
; 205(5): 469.e1-8, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21903191
ABSTRACT
OBJECTIVE:
Placental growth factor and soluble Fms-like tyrosine kinase-1 may be potential diagnostic markers of preeclampsia. We compared performances of 2 immunoassays, the Triage placental growth factor assay and the Elecsys soluble Fms-like tyrosine kinase-1/placental growth factor ratio in diagnosing preeclampsia. STUDYDESIGN:
A single site, case-control study of 44 patients with preeclampsia and 84 matched normal pregnant controls. Samples were collected at the time of diagnosis. Assays were performed according to product inserts.RESULTS:
Both assays had optimal performance in diagnosing early-onset preeclampsia with area under the receiver operating characteristic curves of 0.99 (Triage 100% sensitivity, 96% specificity; Elecsys 64% sensitivity, 100% specificity for early-onset preeclampsia). Reassignment of the Elecsys cutoff for a positive test based on receiver operating characteristic curves increased sensitivity to 92%.CONCLUSION:
Using product insert cutoffs, Triage appears to have greater sensitivity at only a small reduction in specificity compared with Elecsys in the diagnosis of early-onset preeclampsia. A different cutoff may improve Elecsys sensitivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Proteínas da Gravidez
/
Imunoensaio
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Indutores da Angiogênese
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article