[Experiences of liver retransplantation for postoperative diffuse biliary strictures].
Zhonghua Yi Xue Za Zhi
; 91(22): 1529-32, 2011 Jun 14.
Article
em Zh
| MEDLINE
| ID: mdl-21914364
ABSTRACT
OBJECTIVE:
To investigate the feasibility and management of retransplantation for diffuse biliary strictures occurring after initial liver transplantation.METHODS:
The clinical data of 53 consecutive liver retransplantation patients at our hospital from January 2001 to December 2009 were collected and analyzed retrospectively. Among them, 20 (37.7%) were due to diffuse biliary strictures.RESULTS:
Diffuse biliary strictures appeared at 3 - 16 months after initial transplantation. The mean time was 6.3 months. The specific types included intra-hepatic diffuse biliary strictures (n = 16) and multi-strictures involving both intra- & extra-hepatic biliary ducts (n = 4). Retransplantation was performed after a failure of intervention or/and other comprehensive treatments. Among them, 14 were cured and 6 died from peri-operative complications including serious abdominal infection & MODS (multiple organ dysfunction syndrome) (n = 3, 50%), biliary fistula (n = 2, 33.3%) and hepatic artery embolism (n = 1, 16.7%). These patients were followed up for a mean time of 1.8 years (range 1 - 5 years). The accumulative survival rates at 1, 3 and 6 months were 80.0%, 75.0% and 70.0% respectively.CONCLUSIONS:
Liver retransplantation is the ultimate treatment for diffuse biliary strictures after liver transplantation. The survival rate is associated with operative timing, surgical techniques and peri-operative management.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Doenças dos Ductos Biliares
/
Transplante de Fígado
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article