Multicomponent synthesis of artificial nucleases and their RNase and DNase activity.
Beilstein J Org Chem
; 7: 1135-40, 2011.
Article
em En
| MEDLINE
| ID: mdl-21915218
ABSTRACT
The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2011
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Article