[Irinotecan as second-line chemotherapy for 5-FU-resistant gastric cancer with disseminated intravascular coagulation: a case report].
Gan To Kagaku Ryoho
; 38(9): 1517-20, 2011 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-21918353
ABSTRACT
A 60-year-old female was diagnosed as advanced gastric cancer with multiple bone, neck and mediastinal lymph node metastases. As a primary chemotherapy, she was treated with S-1(50 m g/body, twice daily for 4 weeks, followed by a 2- week rest). After 3 courses of S-1, she developed a disease progression with pulmonary lymphangitic carcinomatosis and disseminated intravascular coagulation(DIC). Therefore, she received second-line chemotherapy of irinotecan(CPT-11 150 mg/m2, biweekly). Within 3 weeks of starting the treatment, the clinical and laboratory signs of DIC were dramatically resolved. There have been no previous reports of irinotecan alone showing such remarkable effectiveness in a patient with 5- FU-resistant gastric cancer with DIC.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Camptotecina
/
Terapia de Salvação
/
Coagulação Intravascular Disseminada
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
/
Middle aged
Idioma:
Ja
Ano de publicação:
2011
Tipo de documento:
Article