The effect of plasma removal from apheresis platelet concentrates on platelet function.
Vox Sang
; 102(3): 258-60, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-21923859
ABSTRACT
The effect of plasma removal on platelet function has scarcely been investigated. Plasma removal from apheresis platelet concentrates was achieved by centrifugation at 5000 g for 6 min or 2000 g for 10 min. After resting for 1 h, platelet concentrates were resuspended in 0·9% NaCl. Platelet function was tested before centrifugation and after resuspension by multiple electrode impedance aggregometry (MEA) and light transmission aggregometry (LTA). Plasma removal resulted in 10-14% lower response to TRAP-6 by MEA using both washing procedures, whereas TRAP-6-inducible aggregation by LTA increased slightly (2-5%). Neither plasma removal method affected collagen-induced aggregation. Thus, platelet function did not deteriorate significantly by either method.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasma
/
Plaquetas
/
Ativação Plaquetária
/
Plaquetoferese
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article