Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance.
Diabetes Care
; 13(6): 576-81, 1990 Jun.
Article
em En
| MEDLINE
| ID: mdl-2192845
ABSTRACT
Certain syndromes of extreme insulin resistance are the result of negative-dominant mutations of the insulin receptor. The insulin-receptor heterotetramer appears to be the minimal functional unit for insulin signal transduction probably due to a requirement for intersubunit interactions. The observation that insulin and insulinlike growth factor I receptors can be found in hybrid heterotetramers suggests that insulin receptors can be composed of heterodimers that are the products of separate genes. Such a structure provides a potential molecular mechanism for negative-dominant receptor mutations.
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Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Receptor de Insulina
/
Genes Dominantes
/
Mutação
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article