Effects of proton pump inhibitors in patients with laryngopharyngeal reflux disease.
Hepatogastroenterology
; 58(110-111): 1580-2, 2011.
Article
em En
| MEDLINE
| ID: mdl-21940324
ABSTRACT
BACKGROUND/AIMS:
The effect of proton pump inhibitors (PPIs) on the health-related quality of life (HRQoL) of patients with laryngopharyngeal reflux disease (LPRD) is not well known. Our aim was to assess the HRQoL before and after administration of a PPI in patients with LPRD.METHODOLOGY:
A total of 27 LPRD patients (14 women, 13 men; mean age 54 years) were enrolled. We determined the HRQoL using three different inquiry systems 1) Frequency Scale for the Symptoms of GERD (FSSG); 2) the 36 item short form of the Medical Outcome Study Questionnaire (SF-36); and 3) the Gastrointestinal Symptom Rating Scale (GSRS). The HRQoL was determined at baseline and after eight weeks of treatment with lansoprazole at a dose of 30mg once daily or rabeprazole at a dose of 10mg once daily.RESULTS:
After administration of the PPI, the FSSG, the SF-36 general health scale and mental health scale, GSRS reflux syndrome score, abdominal pain syndrome score and the indigestion syndrome score were significantly improved compared to baseline pretreatment scores (p<0.05).CONCLUSIONS:
PPI therapy would be useful for the treatment of LPRD.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Inibidores da Bomba de Prótons
/
Refluxo Laringofaríngeo
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article