Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries.
Stroke
; 42(12): 3614-5, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21940957
ABSTRACT
BACKGROUND AND PURPOSE:
Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination.METHODS:
Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied.RESULTS:
High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia.CONCLUSIONS:
The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artérias Carótidas
/
Estenose das Carótidas
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Demência
/
Aterosclerose
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article