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Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression.
Liu, Xin-Hua; Yao, Shen; Qiao, Rui-Fang; Levine, Alice C; Kirschenbaum, Alexander; Pan, Jiangping; Wu, Yong; Qin, Weiping; Bauman, William A; Cardozo, Christopher P.
Afiliação
  • Liu XH; Center of Excellence for Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center, Bronx, NY 10468, USA.
Biochem Biophys Res Commun ; 414(1): 165-9, 2011 Oct 14.
Article em En | MEDLINE | ID: mdl-21945932
Nandrolone, an anabolic steroid, slows denervation-atrophy in rat muscle. The molecular mechanisms responsible for this effect are not well understood. Androgens and anabolic steroids activate Notch signaling in animal models of aging and thereby mitigate sarcopenia. To explore the molecular mechanisms by which nandrolone prevents denervation-atrophy, we investigated the effects of nandrolone on Notch signaling in denervated rat gastrocnemius muscle. Denervation significantly increased Notch activity reflected by elevated levels of nuclear Notch intracellular domain (NICD) and expression of Hey1 (a Notch target gene). Activation was greatest at 7 and 35 days after denervation but remained present at 56 days after denervation. Activation of Notch in denervated muscle was prevented by nandrolone associated with upregulated expression of Numb mRNA and protein. These data demonstrate that denervation activates Notch signaling, and that nandrolone abrogates this response associated with increased expression of Numb, suggesting a potential mechanism by which nandrolone reduces denervation-atrophy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Atrofia Muscular / Músculo Esquelético / Peptídeos e Proteínas de Sinalização Intracelular / Receptores Notch / Anabolizantes / Androgênios / Denervação Muscular / Nandrolona Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Atrofia Muscular / Músculo Esquelético / Peptídeos e Proteínas de Sinalização Intracelular / Receptores Notch / Anabolizantes / Androgênios / Denervação Muscular / Nandrolona Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article