Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation.
Food Chem Toxicol
; 49(12): 3038-45, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21946069
ABSTRACT
Mulberroside A was isolated from the ethanol extract of Morus alba roots. The enzymatic hydrolysis of mulberroside A with Pectinex produced oxyresveratrol and oxyresveratrol-3-O-glucoside. We tested oxyresveratrol, oxyresveratrol-3-O-glucoside, and mulberroside A to determine whether they could inhibit ultraviolet B (UVB) irradiation-induced melanogenesis in brown guinea pig skin. Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced the pigmentation in guinea pig skin. These compounds suppressed the expression of melanogenic enzymes tyrosinase, tyrosinase-related protein-1, and microphthalmia transcription factor. The anti-melanogenesis effect was highest with oxyresveratrol, intermediate with oxyresveratrol-3-O-glucoside, and lowest with mulberroside A. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of mulberroside A resulted in enhanced inhibition of melanogenesis. Histological analysis with Fontana-Masson staining confirmed that these compounds significantly reduced the melanin content in the epidermis of UVB-irradiated guinea pig skin compared to the vehicle control. Thus, these compounds effectively reduced pigmentation and may be suitable cosmetic agents for skin whitening.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Raios Ultravioleta
/
Extratos Vegetais
/
Dissacarídeos
/
Glucosídeos
/
Melaninas
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article