Model-specific selection of molecular targets for heart failure gene therapy.
J Gene Med
; 13(10): 573-86, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21954055
ABSTRACT
Heart failure (HF) is a complex multifaceted problem of abnormal ventricular function and structure. In recent years, new information has been accumulated allowing for a more detailed understanding of the cellular and molecular alterations that are the underpinnings of diverse causes of HF, including myocardial ischemia, pressure-overload, volume-overload or intrinsic cardiomyopathy. Modern pharmacological approaches to treat HF have had a significant impact on the course of the disease, although they do not reverse the underlying pathological state of the heart. Therefore gene-based therapy holds a great potential as a targeted treatment for cardiovascular diseases. Here, we survey the relative therapeutic efficacy of genetic modulation of ß-adrenergic receptor signaling, Ca(2+) handling proteins and angiogenesis in the most common extrinsic models of HF.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
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Coração
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Insuficiência Cardíaca
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article