BRCA1 is required for postreplication repair after UV-induced DNA damage.
Mol Cell
; 44(2): 235-51, 2011 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-21963239
ABSTRACT
BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Dano ao DNA
/
Proteína BRCA1
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article