[Hormone therapy effect in postmenopausal women with history of endometrial cancer]. / Efecto de la terapia hormonal en mujeres posmenopáusicas con antecedente de cáncer de endometrio.
Ginecol Obstet Mex
; 79(1): 11-7, 2011 Jan.
Article
em Es
| MEDLINE
| ID: mdl-21966778
ABSTRACT
BACKGROUND:
The increase of endometrial cancer survivors' incidence let the question if the management of postmenopausal hormone therapy will increase the risk of carcinogenesis.OBJECTIVE:
To determine the recurrence rate, in postmenopausal patients managed with hormonal therapy (HT) compared with patients without HT treated in El Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes. PATIENTS ANDMETHOD:
Retrospective, analytical, historical cohort. We analyzed 29 patients who met the inclusion criteria from January 1, 2000 to December 31, 2008RESULTS:
The average age for diagnosis of endometrial cancer was 45 years. 100% of the patients had surgical treatment (82.8% routine endometrial open approach, laparoscopic 17.2%). The 93% of patients had criteria to begin HT, however, was administered alone to 37% due to medical criteria, 36% received tibolona, 64% received estrogen with an average administration time of 39 and 54 months for each one without affecting disease-free period. Patients who received hormonal therapy had no recurrence of disease-free period of 58 months. There was only one patient with recurrence for which no hormonal therapy was administered.CONCLUSIONS:
Patients who were under hormonal therapy did not modify the rate of endometrial cancer recurrence compared with those without HT. Although we cannot conclude irrefutably the safety of hormone therapy, based on biological knowledge and the results of this study, hormone therapy can be safely administered in stage I and II.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Terapia de Reposição de Estrogênios
/
Neoplasias do Endométrio
/
Pós-Menopausa
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Es
Ano de publicação:
2011
Tipo de documento:
Article