Inhibitory effect on NO production of phenolic compounds from Myristica fragrans.
Bioorg Med Chem Lett
; 21(22): 6884-7, 2011 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-21978676
ABSTRACT
Three new phenolics ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Myristica
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Anti-Inflamatórios
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article