Mimosine-induced apoptosis in C6 glioma cells requires the release of mitochondria-derived reactive oxygen species and p38, JNK activation.
Neurochem Res
; 37(2): 417-27, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21986805
ABSTRACT
Growth-inhibitory effects of mimosine, a plant amino acid, on rat C6 glioma cells were analyzed. Mimosine markedly inhibited proliferation and induced apoptosis of C6 glioma cells in a dose- and time-dependent manner. Mimosine-mediated apoptosis was accompanied by promoting reactive oxygen species (ROS) generation in mitochondria, and by decreased mitochondrial membrane potential (Δψ), and release of cytochrome c from mitochondria, followed by caspase 3 activation. Furthermore, mimosine increased the phosphorylation level of c-Jun-N-terminal protein kinase and p38, which was the downstream effect of ROS accumulation. Mimosine was confirmed to show profound effects on apoptosis of C6 glioma cells by ROS-regulated mitochondria pathway, and these results bear on the hypothesized potential for mimosine as promising agents in the treatment of malignant gliomas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Espécies Reativas de Oxigênio
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Apoptose
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MAP Quinase Quinase 4
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Proteínas Quinases p38 Ativadas por Mitógeno
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Glioma
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Mimosina
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Mitocôndrias
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article