[Treatment of haemangiomas of infancy with propranolol; good results, few side effects]. / Behandeling van infantiele hemangiomen met propranolol: goede resultaten en weinig bijwerkingen.
Ned Tijdschr Geneeskd
; 155(40): A3482, 2011.
Article
em Nl
| MEDLINE
| ID: mdl-21988755
ABSTRACT
Infantile haemangiomas (IH) are the most commonly occurring benign tumours of infancy, which may lead to considerable morbidity, such as amblyopia, ulceration and airway obstruction, depending on localization. Until recently, treatment was difficult high-dose systemic glucocorticoids had limited effect and serious side effects. In 2008, the effectiveness of the beta-blocker propranolol for infantile haemangiomas was discovered; by now there is extensive worldwide experience. Data from the literature and from our own patient cohort (n = 132) confirm the remarkable efficacy of propranolol in complicated IH, without significant adverse effects. Propranolol is most effective in the proliferation phase of IH in children under 6 months of age. Timely referral of patients with potentially function-threatening or life-changing IH to a specialised multidisciplinary centre is therefore essential. Pending controlled studies, propranolol appears to have become the first choice treatment in complicated IH.
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Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Antagonistas Adrenérgicos beta
/
Hemangioma
Limite:
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
Nl
Ano de publicação:
2011
Tipo de documento:
Article