Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.
Viruses
; 3(5): 520-40, 2011 05.
Article
em En
| MEDLINE
| ID: mdl-21994744
ABSTRACT
Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD
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Regulação para Baixo
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Infecções por HIV
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HIV
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Liberação de Vírus
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article