[Design, synthesis and Na+/H+ exchanger isoform-1 inhibitory activity of feruloylagmatine analogues].
Yao Xue Xue Bao
; 46(8): 936-41, 2011 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-22007518
ABSTRACT
In order to search for novel inhibitors of Na+/H+ exchanger isoform-1 (NHE-1), nine feruloylagmatine analogues were designed and synthesized from ferulic acid and agmatine. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and mass spectra, among which compounds 5f-5i were novel compounds. The results of preliminary pharmacological test showed that some of the compounds possessed strong NHE-1 inhibitory activity, among which compounds 5a, 5b and 6c were more potent than cariporide in NHE-1 inhibition.
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Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Trocadores de Sódio-Hidrogênio
/
Agmatina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article