Pharmacogenetics in randomized controlled trials: considerations for trial design.
Pharmacogenomics
; 12(10): 1485-92, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-22008051
ABSTRACT
Pharmacogenetic analyses of clinical trials aim to either detect whether a subgroup of patients identified by genetic characteristics responds differently to the treatment or to verify whether a proposed genotype-guided treatment is beneficial over standard care. This article describes three different trial designs, differing in the timing of randomization and genotyping. Each design has its own advantages, and the objectives and conditions under which each one is most suited are discussed.
Texto completo:
1
Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Projetos de Pesquisa
/
Ensaios Clínicos Controlados Aleatórios como Assunto
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article