Control of skin cancer by the circadian rhythm.
Proc Natl Acad Sci U S A
; 108(46): 18790-5, 2011 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-22025708
ABSTRACT
Skin cancer is the most common form of cancer in the United States. The main cause of this cancer is DNA damage induced by the UV component of sunlight. In humans and mice, UV damage is removed by the nucleotide excision repair system. Here, we report that a rate-limiting subunit of excision repair, the xeroderma pigmentosum group A (XPA) protein, and the excision repair rate exhibit daily rhythmicity in mouse skin, with a minimum in the morning and a maximum in the afternoon/evening. In parallel with the rhythmicity of repair rate, we find that mice exposed to UV radiation (UVR) at 400 AM display a decreased latency and about a fivefold increased multiplicity of skin cancer (invasive squamous cell carcinoma) than mice exposed to UVR at 400 PM. We conclude that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Neoplasias Cutâneas
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Carcinoma de Células Escamosas
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Ritmo Circadiano
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Proteína de Xeroderma Pigmentoso Grupo A
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article