Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice.
J Neuroimmunol
; 240-241: 34-44, 2011 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-22030244
ABSTRACT
The effect of a two-week desipramine or fluoxetine (10 mg/kg, i.p.) pretreatment on B16F10 melanoma growth in 3-5 month old female and male C57BL/6J mice differing in behavioral characteristics (high- vs. low-active) was compared. Antidepressant pretreatment increased metastasis formation, shortened the survival, decreased splenocyte anti-tumor natural killer cell cytotoxicity (in vitro), and the pro-inflammatory cytokine IL-12p40, IFN-γ production while it increased anti-inflammatory cytokine IL-10 production in high-active males (desipramine) or females (fluoxetine). The obtained results emphasize a stimulatory effect of pretreatment with antidepressants on progress of B16F10 melanoma that depends on gender and behavioral characteristics of the animal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Melanoma Experimental
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Fluoxetina
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Progressão da Doença
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Desipramina
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Antidepressivos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article