Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients: a preliminary report.
Hum Psychopharmacol
; 26(7): 531-4, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-22031268
ABSTRACT
BACKGROUND:
Depression is a risk factor for coronary heart disease. Nitric oxide (NO) plays an important role in both coronary heart disease and depression.METHODS:
Fifty-one inpatients and outpatients who met the Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition criteria for major depressive disorder (MDD) in the university hospital of the University of Occupational and Environmental Health and 58 age-matched and sex-matched healthy controls enrolled in this study. We investigated the association between the three polymorphisms of the endothelial nitric oxide synthase (eNOS) gene (single-nucleotide polymorphism (SNP); rs2070744, rs1799983, variable number tandem repeat (VNTR) in intron 4) and scores on the Hamilton Rating Scale for Depression, plasma metabolites of NO (NO(x) ) or ankle brachial index in patients with MDD and healthy controls.RESULTS:
We did not find significant differences in the genotype distributions between patients with MDD and healthy volunteers. No associations were observed between any of the polymorphisms of the eNOS gene and the Hamilton Rating Scale for Depression or ankle brachial index in patients with MDD. However, plasma NO(x) level was significantly associated with a polymorphism of the eNOS gene (rs207044 and variable number tandem repeat in intron 4).CONCLUSION:
These results suggest that the direct association was not observed between the polymorphisms of the eNOS gene and the pathogenesis of depression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
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Transtorno Depressivo Maior
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Óxido Nítrico Sintase Tipo III
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Óxido Nítrico
Tipo de estudo:
Guideline
/
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article