Secolignans, neolignans and phenylpropanoids from Daphne feddei and their biological activities.
Chem Pharm Bull (Tokyo)
; 59(11): 1421-4, 2011.
Article
em En
| MEDLINE
| ID: mdl-22041084
ABSTRACT
Two new secolignans and one new neolignan, named feddeiphenols A-C (1-3), together with eight known compounds (4-11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1-11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Lignanas
/
Fármacos Anti-HIV
/
Daphne
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article