How to connect an IgE-driven response with CTL activity?
Cancer Immunol Immunother
; 61(9): 1521-5, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22042251
ABSTRACT
One of the goals of cell-based immune therapy in cancer is the induction of tumor-specific cytotoxic T-lymphocyte (CTL) responses. To achieve this objective, the ability of dendritic cells (DC) to cross-present tumor antigens can be exploited. One of the most efficient pathways for the induction of CTLs by cross-presentation is mediated by immunoglobulins of the IgG class, which are used by DCs to sample antigen in the form of immune complexes via Fc-gamma receptors. Could DCs use an IgE-mediated cross-presentation mechanism in a comparable manner to induce CTLs? We here discuss the potential of two human IgE Fc receptors, FcεRI and FcεRII, to serve as antigen uptake receptors for IgE-mediated cross-presentation. We conclude that the existence of an IgE-mediated cross-presentation pathway would provide a direct link between IgE-driven immune responses and CTL activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Imunoglobulina E
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Linfócitos T Citotóxicos
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Receptores de IgG
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article