Early clinical and structural results after autologous chondrocyte transplantation at the glenohumeral joint.
J Shoulder Elbow Surg
; 21(9): 1213-21, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22047789
ABSTRACT
BACKGROUND:
The purpose of the study was to report early functional and radiographic results of a small series of patients who underwent autologous chondrocyte transplantation-collagen membrane seeding (ACT-Cs) for focal chondral defects of the shoulder.METHODS:
The outcome of 4 consecutive male patients (mean age, 29.3 ± 6.2 years; range, 21-36 years) who underwent ACT-Cs for treatment of large symptomatic glenohumeral cartilage defects was retrospectively evaluated with clinical and radiographic measures at a mean of 41.3 ± 24.9 months (range, 11-71 months) after surgery. The evaluation included a visual analog scale for pain, the Constant score, the American Shoulder and Elbow Surgeons shoulder index, the Rowe score, and a satisfaction scale. Magnetic resonance imaging evaluation was performed according to the Magnetic Resonance Observation of Cartilage Repair Tissue scoring system.RESULTS:
There were 3 humeral full-thickness cartilage defects (each 6.0 cm(2)) and 1 glenoid full-thickness cartilage defect (2.0 cm(2)). The mean postoperative visual analog scale score (0.3 of 10), the mean unweighted Constant score (83.3 ± 9.9), and the mean American Shoulder and Elbow Surgeons index (95.3 ± 8.1) were representative of satisfactory shoulder function. The Magnetic Resonance Observation of Cartilage Repair Tissue score was indicative of satisfactory defect coverage with signs of fibrocartilaginous repair tissue.CONCLUSIONS:
Autologous chondrocyte transplantation at the glenohumeral joint is a remote option for young adults with symptomatic, isolated, large-diameter cartilage lesions. Potential complications as a result of the open approach and 2-step procedure have to be considered carefully. Long-term data, larger patient populations, and randomized studies are required to determine the potential for chondrocyte transplantation techniques to be standard procedure for treatment of symptomatic, large-diameter, full-thickness cartilage defects in the glenohumeral joint.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Articulação do Ombro
/
Cartilagem Articular
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Doenças das Cartilagens
/
Condrócitos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article