Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds.
Dent Mater
; 28(2): 113-22, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22047943
ABSTRACT
OBJECTIVES:
To evaluate the effects of silica (SiO(2)) (0.5 wt%) and zinc oxide (ZnO) (0.25 wt%) dopants on the mechanical and biological properties of tricalcium phosphate (TCP) scaffolds with three dimensionally (3D) interconnected pores.METHODS:
Scaffolds were created with a commercial 3D printer. Post sintering phase analysis was determined by X-ray diffraction. Surface morphology of the scaffolds was examined by field emission scanning electron microscopy (FESEM). Mechanical strength was evaluated with a screw driven universal testing machine. MTT assay was used for cellular proliferation characteristics and cellular morphology was examined by FESEM.RESULTS:
Addition of dopants into TCP increased the average density of pure TCP from 90.8 ± 0.8% to 94.1 ± 1.6% and retarded the ß to α phase transformation at high sintering temperatures, which resulted in up to 2.5 fold increase in compressive strength. In vitro cell-materials interaction studies, carried out using hFOB cells, confirmed that the addition of SiO(2) and ZnO to the scaffolds facilitated faster cell proliferation when compared to pure TCP scaffolds.SIGNIFICANCE:
Addition of SiO(2) and ZnO dopants to the TCP scaffolds showed increased mechanical strength as well as increased cellular proliferation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óxido de Zinco
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Materiais Biocompatíveis
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Fosfatos de Cálcio
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Dióxido de Silício
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Alicerces Teciduais
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article