N-Cyclo-propyl-N-[2-(2,4-difluoro-phen-yl)-2-hy-droxy-1-(1H-1,2,4-triazol-1-yl)prop-yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)acetamide dichloro-methane 0.62-solvate.
Acta Crystallogr Sect E Struct Rep Online
; 67(Pt 9): o2464, 2011 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-22059025
ABSTRACT
In the title compound, C(21)H(22)F(2)N(6)O(4)·0.62CH(2)Cl(2), the difluoro-substituted benzene ring forms dihedral angles of 54.6â
(3)° with the mean plane of the thymine ring and 50.9â
(2)° with the triazole ring. The dihedral angle between the thymine and triazole rings is 7.4â
(3)°. In the crystal, inter-molecular N-Hâ¯N and O-Hâ¯O hydrogen bonds link the main mol-ecules into chains along [10[Formula see text]]. The CH(2)Cl(2) solvent mol-ecule was refined as partial occupancy over two sets of sites with refined occupancies of 0.308â
(9) and 0.310â
(8).
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MEDLINE
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En
Ano de publicação:
2011
Tipo de documento:
Article