An anionic exchange stir rod sorptive extraction based on monolithic material for the extraction of non-steroidal anti-inflammatory drugs in environmental aqueous samples.

ABSTRACT

In this study, a stir rod sorptive extraction (SRSE) adsorbent material was prepared by coating poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) [poly(VP-co-EDMA)] monolithic polymer on stir rod, and then applied to the extraction of three non-steroidal anti-inflammatory drugs (NSAIDs) in environmental aqueous samples. The preparation conditions of monolithic material such as the amount of porogen and the ratio of functional monomer to cross-linker were investigated. To achieve the best extraction efficiency, several parameters, including pH value of sample solution, salt concentration in sample matrix, desorption solvent, extraction time, and desorption time, were optimized. By combining SRSE and high performance liquid chromatography with ultraviolet detector, a SRSE-HPLC/UV method for the determination of NSAIDs in environmental aqueous samples was proposed successfully. The limits of detection (LODs) of the developed method for three NSAIDs ranged between 0.09 and 0.25 ng/mL. Good method reproducibility presented as intra- and inter-day precisions were also obtained with the relative standard deviations (RSDs) less than 8.7% and 9.8%, respectively.