Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties.
Molecules
; 16(11): 9368-85, 2011 Nov 08.
Article
em En
| MEDLINE
| ID: mdl-22068619
ABSTRACT
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as 0.32, 0.67, 1.19 and 1.22 µM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Cloro
/
Indóis
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article