Compatibility of different polymers for cord blood-derived hematopoietic progenitor cells.
J Mater Sci Mater Med
; 23(1): 109-16, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22071984
ABSTRACT
The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Materiais Biocompatíveis
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Células-Tronco Hematopoéticas
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Sangue Fetal
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article