The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines.
Cancer Lett
; 53(2-3): 103-8, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-2208068
ABSTRACT
The sulfur-containing compound ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) which arises from alliin, a cysteine derivative stored in garlic bulbs, was produced synthetically by decomposition of allicin. Its cytotoxic effect was tested using human primary fibroblasts (FS4), a permanent, non-tumorgenic cell line derived from baby hamster kidney cells (BHK21) and a tumorgenic lymphoid cell line derived from a Burkitt lymphoma (BJA-B). The cytotoxic action was in the range 2-50 micrograms/ml depending on the cell density. ED50 values, estimated on the basis of fmol ajoene/cell, revealed slightly higher doses for the primary cell (FS4) than the permanent line (BHK), whereas the tumorgenic BJA-B cells were most sensitive.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Sobrevivência Celular
/
Dissulfetos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article