Common fragile sites: mechanisms of instability revisited.
Trends Genet
; 28(1): 22-32, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22094264
ABSTRACT
Common fragile sites (CFSs) are large chromosomal regions prone to breakage upon replication stress that are considered a driving force of oncogenesis. CFSs were long believed to contain sequences blocking fork progression, thus impeding replication completion and leading to DNA breaks upon chromosome condensation. However, recent studies show that delayed completion of DNA replication instead depends on a regional paucity in initiation events. Because the distribution and the timing of these events are cell type dependent, different chromosomal regions can be committed to fragility in different cell types. These new data reveal the epigenetic nature of CFSs and open the way to a reevaluation of the role played by these sites in the formation of chromosome rearrangements found in tumors from different tissues.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Instabilidade Genômica
/
Sítios Frágeis do Cromossomo
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article