In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
Antimicrob Agents Chemother
; 56(2): 1135-7, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22106211
ABSTRACT
AIC246 (letermovir) is a potent anticytomegalovirus drug in clinical development. Here, we report a consistent antiviral efficacy of AIC246 against human cytomegalovirus laboratory strains, clinical isolates, and virus variants resistant to approved drugs. Furthermore, we describe a remarkable selectivity of AIC246 for human cytomegaloviruses compared to that of other alpha-, beta-, or gammaherpesviruses or nonrelated pathogenic viruses, including adeno-, hepadna-, retro-, orthomyxo-, and flaviviruses. Our data confirm and support an excellent and selective anticytomegaloviral activity of AIC246.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Quinazolinas
/
Infecções por Citomegalovirus
/
Citomegalovirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article