A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3).
Int J Lab Hematol
; 34(3): 328-32, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22122800
ABSTRACT
Although most patients with peripheral T-cell lymphoma (PTCL) show clonal rearrangement of T-cell receptor genes, few PTCLs show recurrent chromosomal abnormalities. We describe here a rare chromosomal rearrangement, t(14;19)(q11.2;q13.3), in a Lennert's lymphoma, a variant of PTCL, not otherwise specified. Sequential fluorescence in situ hybridization assays showed that the breakpoint in 19q13.3 was located distal to the BCL3 and PVRL2 genes, both of which may be candidate proto-oncogenes. These findings suggest that another gene is involved in the pathogenic characteristics observed in this patient with Lennert's lymphoma.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 14
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Cromossomos Humanos Par 19
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Linfoma de Células T Periférico
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Aberrações Cromossômicas
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article