Determination of vitamin B6 by means of differential spectrophotometry in pharmaceutical preparations in the presence of magnesium compounds.
Acta Pol Pharm
; 68(6): 845-51, 2011.
Article
em En
| MEDLINE
| ID: mdl-22125948
ABSTRACT
The content of pyridoxine hydrochloride in two-component pharmaceutical preparations containing various magnesium compounds was examined. The UV differentiation spectrophotometry was devised and compared with the reference method of high performance liquid chromatography (HPLC). The analysis of the absorbance spectra (A) and its first (D1) and second (D2) derivatives made it possible to establish the appropriate analytical wavelengths (A 290 nm; D1 302 nm; D2 308 nm). It was proved that spectrum differentiation significantly corrects errors resulting from overlapping background especially when the magnesium hydroaspartate, lactate or magnesium lactogluconate is present together with vitamin B6.
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Base de dados:
MEDLINE
Assunto principal:
Piridoxina
/
Espectrofotometria Ultravioleta
/
Preparações Farmacêuticas
/
Tecnologia Farmacêutica
/
Compostos de Magnésio
/
Vitamina B 6
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article